Engineering Cell-Specific delivery of therapeutic programs via cell-classifier circuits encoded on self-amplifying RNA Fabio Caliendo Department of Biological Engineering; Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA, USA
2
Unravelling the role of ZCCHC24 in gastric cancer Maria Barbara Campbell Department of Biosciences, University of Milan, Italy
3
Aptamer-Based GANAB Enzyme Blockade Guided by Artificial Intelligence for Therapeutic Intervention in Pancreatic Cancer Anna Drabik Department of Analytical Chemistry and Biochemistry, AGH University of Science and Technology, Krakow, Poland
4
RMEL3 lncRNA Drives Melanoma Cell Survival and Immune Modulation via Isoform-Specific Functions Enilza M. Espreafico Department of Cell and Molecular Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil
5
Isoform-Resolved RNA-Sequencing with RNA BaseCode Gert-Jan Hendriks Basic Genomics AB, Solna, Sweden
6
Drug-like Molecular Degraders of the Oncogenic RNA-Binding Protein HuR Liann Kassabri The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, IL
7
Innovative strategy using mRNA-LNP for the treatment of hematologic disorders Chantal Lagresle-Peyrou Biotherapy Clinical Investigation Center, Groupe Hospitalier Universitaire Ouest-APHP, Université Paris Cité, Imagine Institute, INSERM UMR 1163, Paris, France
8
Epigenetic regulator silencing by siRNA for the treatment of metabolic diseases Seunghee Lee Research Institute of Pharmaceutical Sciences, Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, Korea
Antineoplastic targeted therapy: Identifying and manipulating cancer associated fibroblasts (CAFs) with aberrant mechanotransduction Francesca Nonatelli Instituto de Biotecnología y Biomedicina de Cantabria (IBBTEC), CSIC/Universidad de Cantabria, Santander, Spain
11
Novel approach to PK bioanalysis of oligonucleotide therapeutics using Nucleic Acid Nanorobotics (NANs) Maria Oranges Nanovery Ltd, UK
12
Target Capture SELEX (TACS) enables the design of U1 snRNP riboswitches for conditional gene expression control in mammalian cells Fernando Pastor Therapeutic Innovation, Aptamer Unit, (CIMA), University of Navarra (UNAV), Pamplona, Spain
13
Splicing Modulation as an Unintended NMD Inhibition Pathway with Therapeutic Potential in Cancer Fernando Pastor Therapeutic Innovation Program, CIMA, University of Navarra, Pamplona; CIBERONC, Madrid, Spain
14
Perturbation of RNA splicing fidelity hampers pancreatic cancer cell viability by disrupting DNA repair proficiency and mitotic checkpoint integrity Marco Pieraccioli Catholic University of the Sacred Heart; Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
15
Investigating CDK12 and CDK13 as Therapeutic Targets in Group 3 Medulloblastoma Consuelo Pitolli Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, Rome, Italy
16
The Alternative Splicing of NF-YA Regulates rouse Embryonic Stem Cells differentiation Sofia Polettini Department of Biosiences, Università degli Studi di Milano, Italy
17
In vivo evaluation of optimized anti-hypoxia miRNA-6883 lipid nanoparticles in colorectal and breast cancer for CDK4/6 and HIF silencing Connor Purcell Laboratory of Translational Oncology and Experimental Cancer Therapeutics; Department of Pathology and Laboratory Medicine; Legorreta Cancer Center, The Warren Alpert Medical School, Brown University, Providence, RI, USA
18
A robust ELISA-like hybridization assay for the detection of therapeutic oligonucleotides Nicholas Rice ADViRNA, Worcester, MA, USA
19
Target. Silence. Transform: Advancing ASO Therapeutics with Sai Life Sciences Abhishek Sinha Sai Life Sciences, Medchal-Malkajgiri District, Telangana, India
20
The Role of NAD and Non-Canonical Caps in RNA-RNA interaction Ambra Spampinato Institute of Organic Chemistry and Biochemistry, Academy of Sciences of Czech Republic, Prague, Czech Republic
21
A novel circular RNA-based therapeutical platform for infectious and non-infectious diseases Marc Talló-Parra NoctuRNA Therapeutics; Molecular Virology Group, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain
22
mRNA-based strategy for the prophylaxis of Plasmodium falciparum malaria Alexander Welch Oxford University: Collaboration between Furger Lab and Draper Lab, UK
23
Targeting aberrant mRNA splicing driven by mutant p53 as a novel cancer therapeutic approach Weronika Wojtyś Mossakowski Medical Research Institute, Polish Academy of Sciences, Poland
24
Selective Enrichment of Circular RNAs in Extracellular Vesicles released by Ovarian Cancer Cells: A New Frontier in Liquid Biopsy Giuseppe Cammarata Institute of Translational Pharmacology (IFT), National Research Council of Italy (CNR), Palermo, Italy
25
New Zealand RNA Platform Caitlin MacArthur Malaghan Institute of Medical Research, New Zealand